Publications

Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex

Peters AJ, Marica A-M, Fabre JMJ, Harris KD, Carandini M

Cell Reports 2022

A specific zone in the medial prefrontal cortex (mPFC) becomes responsive to visual stimuli when mice learn to associate them with a movement. This suggests that information about behaviorally relevant stimuli becomes routed to the mPFC with learning.

Striatal activity topographically reflects cortical activity

Peters AJ, Fabre JMJ, Steinmetz NA, Harris KD, Carandini M

Nature 2021

Patterns of summed activity are matched between topographically connected regions of the cortex and striatum, changing only in gain with learning. This suggests that the cortex and striatum operate in sync with each other, and become more tightly locked together by learning.

Learning in the rodent motor cortex

Peters AJ, Liu H, Komiyama T

Annual Review of Neuroscience 2017

A review of structural and functional changes in the motor cortex accompanying motor learning. The motor cortex is implicated in controlling movement but it is very malleable with learning, suggesting that it is not merely a conduit to the spinal cord but actively changes to better drive learned and dextrous movements.

Reorganization of corticospinal output during motor learning

Peters AJ, Lee J, Hedrick NG, O'Neil K, Komiyama T

Nature Neuroscience 2017

Patterns of summed activity are matched between topographically connected regions of the cortex and striatum, changing only in gain with learning. This suggests that the cortex and striatum operate in sync with each other, and become more tightly locked together by learning.

Emergence of reproducible spatiotemporal activity during motor learning

Peters AJ, Chen SX, Komiyama T

Nature 2014

Activity in L2/3 of the motor cortex is flexibly related to movement, becoming more consistent for learned movements. This suggests that networks of neurons one step before cortical output become specialized for learned movements.